Leadership & Executive Team

Chief Executive Officer

Paul Higham

Chief Operating Officer

Shelley Cook PhD

Executive Chair & Co-Founder

Tom McCarthy PhD

VP, Drug Discovery

David Miller PhD

VP, Biology

Barbara Cipriani PhD

Head of Clinical Operations

Debbie Macaro

Director, Clinical Operations

Anthony J. Good, PhD

Chief Medical Officer

Dr. Sumeet Ambarkhane

Head of CMC & Clinical Supplies

Ann Taylor-Hutchinson

Chief Executive Officer

Paul Higham

Paul is Chief Executive Officer of Pathios and brings extensive leadership experience from both large pharmaceutical and biotech companies. He has over 20 years’ of C-Suite biotech experience covering both public and private companies with the focus for the last 15 years being in the immuno-oncology space. During this time Paul has led three IO-focused companies (Immatics, Glycotope and ValoTx) as CEO, in each creating value by progressing through pre-clinical to the clinic and guiding late-stage clinical development programs. In his earlier career in large pharma, (Bayer and GSK) he gained wide ranging experience in marketing, commercialisation, commercial strategy, business development and finance. He holds an honours degree in Applied Biology.

Chief Operating Officer

Shelley Cook PhD

Shelley has built out and led Operations and championed a culture to support high-performing teams in a number of growing Biotechs and business units. She also has demonstrable Strategic, Licencing and Alliance Management experience at senior level. Prior to this, Shelley was a Life Science Equity Research Analyst. She graduated with a BA and MSc in Bioscience and DPhil in Emerging Tropical Viruses from University of Oxford, UK, and completed her post-doctoral studies as a Sir Henry Wellcome Fellow at the Natural History Museum, UK and Aix Marseille Université, France.

Executive Chair & Co-Founder

Tom McCarthy PhD

Tom is a Co-Founder and Executive Chairperson of Pathios Therapeutics and brings over 25 years of experience in drug discovery, development and commercialization to the team. Pathios Therapeutics was created by, and continues to be incubated within, Molecule to Medicine (MTM; previously referred to as M:M Bio or M2M). MTM is a UK, EU and Australian-based organisation that Tom and Kirsty McCarthy created that brings together entrepreneurs and experts to co-create and scale biotech companies within MTM’s global ecosystem. Additional current MTM portfolio companies includes ThirtyFiveBio, Melio Bio, Lucia Bio and Curlew Bio, where he is Co-Founder and/or Executive Chairperson. Additional companies created by MTM include Grey Wolf Therapeutics and he continues to Chair the Board. His further roles include Chair of Orbit Discovery and Venture Partner at Brandon Capital.

Prior to co-creating the MTM ecosystem of biotech companies, he was President and CEO of Spinifex Pharmaceuticals, a private VC backed US/Australian biotech company developing first in class treatments for chronic pain, devoid of central nervous system side-effects. Spinifex Pharmaceuticals was purchased by Novartis in 2015 for approximately US$700 million. Previous positions include Vice President of Drug Development at Starpharma Holdings (Australia). He holds BSc (Hons) and PhD degrees from Monash University, Australia and completed his postdoctoral training at The University of Oxford.

VP, Drug Discovery

David Miller PhD

David is the VP of Drug Discovery at Pathios and brings 25 years of experience to the company in terms of designing potent and novel molecules, DMPK, IP, project leadership and compound progression into clinical trials. Working across multiple therapeutic areas, David has previously held positions at Organon Laboratories in Scotland and at Amedis Pharmaceuticals, Paradigm Therapeutics and Takeda in Cambridge. Most recently David was a key member of the team at Inflazome which delivered two compounds into clinical trials and was recently acquired by Roche.

VP, Biology

Barbara Cipriani PhD

Barbara is Head of Biology at Pathios. She has a PhD in Immunology and brings over 17 years’ experience in drug discovery, gained first at MSD then at Vertex Pharmaceuticals. At MSD she worked on developing anti-cancer vaccines and immuno-oncology assets. She then joined Vertex Pharmaceuticals where she led immunology efforts in the areas of inflammation, autoimmunity and immuno-oncology. In this role she set-up complex immunological assays and developed biomarkers to advance drug candidates. More recently at Vertex Barbara served as project leader, managing programs related to rare CNS disorders involving inflammation and autoimmunity. She also led a team to establish in vitro disease models using human pluripotent stem cells and gene editing to support additional programs.

Head of Clinical Operations

Debbie Macaro

Debbie is Head of Clinical Operations at Pathios Therapeutics. She provides program oversight for the preparation and execution of the clinical development program. She has over 20 years experience in clinical research both in small biotech and large pharmaceutical companies. She has successfully operationalised Phase 1-3 clinical research studies in many regions including EU, UK, US and APAC. Debbie has a B.Sc(Hons) from Bradford University, UK.
Director, Clinical Operations

Anthony J. Good, PhD

Leveraging over 25 years of experience in Clinical Development, Anthony is responsible for leading Clinical Operations in Australia for Pathios Therapeutics. Renowned for his scientific acumen and strategic leadership, Anthony has guided global clinical development programs across a diverse range of therapeutic areas, including Immuno-oncology, Immunology, Cardiovascular, Central Nervous System, Infectious Diseases, Metabolic and Endocrine, Allergy and Respiratory, and Sexual Health.

Throughout his career, Dr. Good has held pivotal roles in both academic and industrial settings, contributing significantly to the advancement of pharmaceutical science. Prior to his current position, Anthony served as Snr VP Clinical Research, Imugene Ltd, where he demonstrated his proficiency in guiding early-stage drug development programs from inception to successful FDA IND approvals and through phase 1 and 2 development. Dr. Good’s commitment to excellence is underscored by his track record in leading clinical teams and study staff to ensure the seamless implementation of clinical studies in alignment with development plans. His strategic leadership and interactions with opinion leaders and regulatory agencies have been instrumental in the successful execution of global clinical programs on time and within budget.

A passionate advocate for translating novel science into transformative medicines, Anthony’s contributions to the pharmaceutical industry have been significant and far-reaching. He holds a PhD in Neuroscience and BSc (Hons) in Psychology, both awarded by the University of New South Wales. Anthony’s dedication to advancing healthcare through innovative clinical development makes him a valued leader in the field.

Chief Medical Officer

Dr. Sumeet Ambarkhane

Dr. Sumeet Ambarkhane is a seasoned physician-scientist with over 20 years of experience in clinical medicine, drug development, and regulatory strategy. As Chief Medical Officer at Pathios, he brings a wealth of expertise in advancing novel therapeutics from early research through clinical development and approval, commercialization and pharmaceutical collaborations. His career spans key leadership roles in global pharmaceutical and biotechnology companies including UCB, MorphoSys and Alligator Bioscience, where he has been instrumental in guiding the development of groundbreaking therapies across immuno-oncology, hematology, immunology, as well as neurology.

Dr. Ambarkhane’s experience extends across all phases of drug development, from first-in-human trials to late-stage clinical programs, with a strong focus on designing and executing clinical strategies that bring transformative therapies to patients in an accelerated manner. With a deep understanding of both scientific innovation and the rapidly evolving regulatory landscape, Dr. Ambarkhane is committed to translating cutting-edge research into real-world treatment options.

Dr. Ambarkhane holds a medical degree and doctorates in medicine and clinical pharmacology from Seth G.S. Medical College and King Edward Memorial Hospital, University of Mumbai, India.

Head of CMC & Clinical Supplies

Ann Taylor-Hutchinson

As the Head of CMC and Clinical Supplies, Ann joined Pathios to align the CMC deliverables with the evolving development program of PTT-4256. Her focus is on delivering compliant, phase-appropriate solutions within accelerated timelines. With extensive experience in advancing drug substance and drug product programs from concept to commercial launch readiness, she has proven expertise in CDMO oversight, outsourcing strategies, supply chain logistics, regulatory submissions, analytical and formulation development, and GMP manufacturing.

Before joining Pathios, Ann worked at several biotechs, including Reneo Pharma and Oxford Pharmascience. With a background in analytical chemistry, she has experience across various dosage formats, having held positions at Molecular Profiles, Innovata Biomed, Reckitt Benckiser/Boots Healthcare International, and Boots Contract Manufacturing and Analytical Services. Ann holds a BSc (Hons) in Applied Chemistry from Nottingham Trent University and is also a named inventor on a patent application.

Core Scientific & Project Management Team

Sr. Drug Discovery Advisor & Co-Founder

Alan Naylor PhD

Senior Scientist

Alastair Corbin DPhil

Clinical Development Scientist

María José Oliva-Martín PhD

Business Development & Competitive Intelligence Manager

Sam Letcher

Strategic Communications & Branding Manager

Tinotenda Rwodzi

Executive Assistant

Liz Robinson

Clinical Operations Lead

Sanjay Patel

Clinical Trial Specialist

Seint Thè Su Lwin, DPhil

Sr. Drug Discovery Advisor & Co-Founder

Alan Naylor PhD

Alan is Head of Drug Discovery and Co-founder at Pathios. Alan is a medicinal chemist with over 30 years experience in Research and Development within GlaxoSmithKline. He previously held the position of Vice President and Director of Medicinal Chemistry within the GSK Drug Discovery organization and has led strategic, matrix and line functions involving significant international responsibilities. He has an extensive track record of success, across a wide range of therapeutic areas, having played a major role in the discovery of over 30 development compounds, and is a co-inventor of Serevent, a major advance in the treatment of asthma. Alan also acts an independent consultant providing scientific and strategic advice and analysis to major pharma, biotechnology companies, academic groups, capital investment companies and funding bodies on a variety of issues within the drug discovery and healthcare sector.

Senior Scientist

Alastair Corbin DPhil

Alastair is a Senior Scientist at Pathios, and brings nearly 10 years of experience in biomedical research & drug discovery across inflammatory, cardiovascular, and neuropathic disease. At Pathios, Alastair provides expertise in mononuclear phagocyte immunology, flow cytometry, and in vivo models to support and direct R&D activities. Before joining Pathios, Alastair worked at Ipsen Bioinnovation where he advanced the neurotoxin portfolio by designing and conducting biological and biophysical assays to determine efficacy and binding properties of modified recombinant neurotoxins. Prior to Ipsen, Alastair spent 6 years researching innate immunology, investigating the role of IRF5 in directing intestinal inflammation and repurposing an existing small molecule for the treatment of inflammatory bowel disease. Alastair holds a DPhil in Cellular and Molecular Medicine from University of Oxford, and a BSc(Hons) in Medical Biochemistry from University of Manchester.

Clinical Development Scientist

María José Oliva-Martín PhD

María José is a Clinical Development Scientist at Pathios, bringing nearly 15 years of experience in biomedical research focused on inflammation and immuno-oncology. In her current role at Pathios, she leads scientific and high-quality execution of the RAISIC-1 clinical program, data analysis and interpretation, ensuring regulatory, operational, and scientific standards.

Before joining Pathios, María José served as a Preclinical Senior Scientist at Immunocore, where she led the preclinical efforts for an immuno-oncology target and developed a CRISPR team along with workflow processes for the efficacy and safety assessments of candidate molecules. Prior to her time at Immunocore, she spent five years in academic research, investigating the roles of the cell death proteins caspase-8 and RIPK1 in the activation and differentiation of macrophages, as well as their implications in disease.

During her extensive academic career, María José obtained a PhD in Biomedicine and Molecular Biology from the University of Seville, an MPhil (Hons) in Translational Medicine and Therapeutics from the University of Cambridge, and an MPharm from the University of Seville.

Business Development & Competitive Intelligence Manager

Sam Letcher

Sam serves as the Business Development & Competitive Intelligence Manager at Pathios, focusing on shaping strategic messaging for investors and partners while overseeing corporate contracting and data-room governance. Having navigated roles across both R&D and Clinical Operations, including a recent 18-month secondment in Australia, Sam excels at grounding commercial discussions in operational reality.

He is a key driver of Pathios’ agile operating model, leveraging his project management expertise to enhance cross-functional execution and competitive intelligence workflows. Sam earned his MSci in Chemistry from University College London and previously specialised in the immunotherapy sector as a conference producer.

Strategic Communications & Branding Manager

Tinotenda Rwodzi

Tino leads the development and execution of Pathios’ scientific, corporate, and brand communications. She oversees communication strategies spanning brand positioning, digital communications and manages the strategic delivery and operational phases of scientific publications.

With a background in biomedical science and hands-on project management experience across R&D programs, including CMC & clinical supply chain, pre-clinical and clinical development, and grant management, Tino brings a deep understanding of the drug development lifecycle to her role. This enables her to translate complex scientific and operational milestones into compelling communications that build confidence, support growth, and reinforce Pathios’ strategic vision.

Tino holds a First Class BSc (Hons) in Biomedical Science from the University of Westminster.

Executive Assistant

Liz Robinson

Liz is Executive Assistant at Pathios, providing essential support to the C-Suite and ensuring seamless coordination across all levels of the business. She graduated with a First Class BSc (Hons) in International Hospitality Management and has since accumulated diverse experience from various industries, including IT and Oil & Gas, most recently working as Operations Manager for a design and manufacturing company.

Clinical Operations Lead

Sanjay Patel

Sanjay is the Clinical Operations Lead for Pathios in Europe for Pathios.

Sanjay has extensive experience developed over a period of 35 years through working at a range of small and medium-sized global and UK-based biotech companies. He specialises in early-stage oncology studies and has experience in the setup, management and successful delivery of global clinical trials and programs for novel investigational medicinal products, including radio-immunotherapy and complex cell therapies and small molecules.

As a Medicinal Chemist by training, prior to clinical operations, Sanjay enjoyed a successful career managing large medicinal chemistry teams and drug discovery projects. Sanjay has a BSc(Hons) in Chemistry from the University of Wales Institute of Science and Technology, UK.

Clinical Trial Specialist

Seint Thè Su Lwin, DPhil

As a Clinical Trial Specialist at Pathios, Seint supports various trial activities – coordinates and collaborates with cross-functional teams to ensure the efficient execution of clinical trials. Seint has over 15 years of experience in biomedical research in cardiology, pharmacology, bone biology and oncology. Prior to joining Pathios, Seint was a Senior Scientist in the Pipeline and Pre-Clinical Department before joining the Clinical Development Operations as a Clinical Trial Support Specialist at Adaptimmune Ltd.

Seint holds a DPhil in Bone Oncology from the University of Oxford, Master of Science and Bachelor of Science in Biological Sciences from Tennessee State University.

MTM Key Team Members & Advisors

Advisor

Stuart Hughes PhD

Co-Founder & MTM CEO

Kirsty McCarthy MBA

Advisor & Co-Founder

Peter Joyce PhD

Advisor

James Westcott PhD

Head of Corporate Governance & Business Operations Manager

Sam Harris

Director of Finance

Lisa Shoesmith

Head of People

Andrea Nisbet

Executive Assistant & Facilities Manager

Sean Carroll

Lead Bioinformatician

Danish Memon

Management Accountant

Luke Griffiths

Senior Scientist, Translational Informatics

David Smith-Parkin

Advisor

Stuart Hughes PhD

As of 1st of March, Stuart Hughes (previous CSO) has moved on to pursue a new opportunity. We wish him the best and will be continuing to work with Stuart in an advisory role.

Stuart has over 20 years experience in scientific leadership and drug discovery expertise. Stuart has worked across several therapeutic areas inlcuding CNS disorders, immunology and oncology and has deep expertise in guiding early stage drug discovery programs from inception toward clinical development. Stuart has gained wide-ranging experience from positions in both academic and industrial settings. Previous positions include Research Fellow and Senior Lecturer at Cardiff University, Principal Research Scientist at Eli Lilly and most recently, Senior Director at Vertex Pharmaceuticals. He holds a a PhD in Neuroscience from Cardiff University, a BSc in Pure and Applied Mathematics and an MSc in Electronic Engineering.

Co-Founder & MTM CEO

Kirsty McCarthy MBA

Kirsty is Co-founder at Pathios and CEO of Molecule to Medicine (MTM). Kirsty has a track record in founding and running two companies based on intellectual property from Australia’s then government funded telecommunications research laboratory in the areas of voice recognition and the analysis of “big data”, the latter directly relevant to bioinformatics applications in life science companies. She is an MBA graduate from University of Melbourne following undergraduate studies at Monash University and The University of Queensland.

Advisor & Co-Founder

Peter Joyce PhD

Peter is an advisor to Pathios and co-founder. He is also co-founder and Chief Executive Officer of Greywolf Therapeutics and has over 13 years of experience in biomedical research leading drug discovery projects in immuno-oncology, rare genetic diseases and neurodegeneration. In his previous role at Vertex Pharmaceuticals, he led drug discovery projects, had responsibility for leading a number of target identification teams that led to multiple novel drug discovery projects and was involved in delivering clinical drug candidates. He also pioneered the development of complex neurological assays suitable for assessing the functional impact of optimized compounds. Prior to Vertex, Peter was an MRC Research Fellow investigating the pathophysiology and underlying mechanisms of neurodegeneration and publishing multiple first and co-author publications. Peter holds a PhD in Biochemistry and Molecular Genetics from the University of Bristol and a BSc in Biochemistry.

Advisor

James Westcott PhD

James is an adviser to Pathios and is also Chief Executive Officer of ThirtyFiveBio. James brings over 20 years of drug discovery industry experience working in therapeutic areas such as oncology, immuno-oncology and rare disease to enable target identification, validation and clinical candidate delivery. Previous positions include being part of the research leadership team at Vertex Pharmaceuticals’ Oxford research centre, project leader/lead biologist on various discovery projects and head of the primary pharmacology, enzymology and high-throughput screening groups. James has worked extensively on small molecule modality projects and recently with PROTAC and anti-sense oligonucleotide approaches against a range of targets including enzymes, GPCRs and ion channels. James received his PhD in Biochemistry from the University of Bristol and 1st class honours BSc in Chemistry from the University of Aston.

Head of Corporate Governance & Business Operations Manager

Sam Harris

Sam Harris is the Head of Corporate Governance & Business Operations Manager for MTM. She graduated from Aston University with a BSc with Honours degree in International Business and Modern Languages (French), which included a year at one of France’s top Business Schools – EDHEC. Since leaving University she has spent the last 20yrs of her career providing EA & operational support to C Suite Executives and their Leadership teams, ensuring the smooth running of their businesses incorporating all aspects of people, places and processes. Sam has worked in several industries including Consumer Packaging, Mobile software, Information Technology, and prior to joining MTM, 7 years within the advertising technology sector.

Director of Finance

Lisa Shoesmith

Lisa is Director of Finance at MTM. Having completed a BA (Hons) in Accountancy & Management Control, Lisa qualified as a Chartered Accountant ICAEW with Mazars in 2000. Since qualifying, Lisa has held various finance and operational roles within both the private and public sector with a focus on working with SMEs and she brings this experience with her to her role here.

Head of People

Andrea Nisbet

With over 25 years working as an HR specialist, Andrea has successfully delivered projects around organisation design, TUPE, large scale redundancies, performance design, culture and employee engagement, leadership and employee development. Previously, Andrea worked for Berendsen UK Ltd as HR Director for the Hospitality Business Line where she was responsible for the HR function for 3000 employees across UK, Ireland, Denmark and Sweden. Andrea is a Chartered Member of the CIPD, a Mental Health First Aider and a registered practitioner in DISC and Hogan psychometric testing.

Executive Assistant & Facilities Manager

Sean Carroll

Sean is an International Business BSc (Hons) graduate from Oxford Brookes University and is Executive Assistant at Pathios. Sean has over 10 years experience in hospitality and customer relations, as well as supporting C-Suite executives across both public and private sector organisations.

Lead Bioinformatician

Danish Memon

Danish s a lead bioinformatician in MTM where he provides insights from large datasets to understand the biology and therapeutic potential of drug targets in oncology space. He has several years of experience consulting with biotech companies for target identification, evaluation of valuable drug assets, disease indication selection and biomarker development for clinical trials. Prior to this, Danish completed his postdoctoral training in the University of Cambridge and the European Bioinformatics Institute where he worked on integration of multi-omics data to address key questions related to genomic regulation of signalling networks in cancer and characterization of the tumour-immune microenvironment in treatment-naive and treatment-resistant patient populations. Originally from India, Danish has a bachelor’s degree in Biotechnology and a master’s degree in Bioinformatics. He moved to the UK to pursue doctoral studies in computational oncology in the University of Manchester.

Management Accountant

Luke Griffiths

Luke has held a variety of roles since beginning his career in finance in 2019, across the retail and publishing sectors. After qualifying as a Chartered Certified Accountant in 2024, Luke now works as a management accountant for Pathios Therapeutics, supporting the team with all financial and performance reporting.

Senior Scientist, Translational Informatics

David Smith-Parkin